Antibody drug conjugates

Targeted Drug Delivery: Leveraging VHHs to Enhance Specificity and Reduce Side Effects

Many small molecule drugs are known to cause side effects, stemming from their ability to non-specifically target healthy cells or tissue in addition to infected cells. Ideally, a drug only acts where it is supposed to act. Such drugs can be coupled onto a VHH which will direct and deliver the drug at a specific site based on its ability to interact with i.e. a receptor on target cells. The VHH is then used as a specificity key. Since VHH cDNA is available by default, its genetic code can be adapted according to needs, enabling click reactions or maleimide chemistry for site-specific coupling to the VHH without the latter loosing its biological activity or specificity.