{"id":5014,"date":"2024-10-21T11:21:07","date_gmt":"2024-10-21T11:21:07","guid":{"rendered":"https:\/\/explorelogicsit.net\/gulliverbiomed\/?post_type=konta_service&#038;p=5014"},"modified":"2024-10-28T11:21:36","modified_gmt":"2024-10-28T11:21:36","slug":"vhh-gene-therapy-small-size","status":"publish","type":"konta_service","link":"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/vhh-gene-therapy-small-size\/","title":{"rendered":"VHH Gene Therapy (small size)"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"5014\" class=\"elementor elementor-5014\" data-elementor-post-type=\"konta_service\">\n\t\t\t\t<div class=\"elementor-element elementor-element-aa2eda9 e-flex e-con-boxed e-con e-parent\" data-id=\"aa2eda9\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-2f7353a e-con-full services-sider-bar e-flex e-con e-child\" data-id=\"2f7353a\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-9800363 e-con-full e-flex e-con e-child\" data-id=\"9800363\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5f953bd elementor-widget elementor-widget-heading\" data-id=\"5f953bd\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Applications<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9aa33cb elementor-widget__width-initial elementor-widget elementor-widget-spacer\" data-id=\"9aa33cb\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8fe0609 elementor-nav-menu--dropdown-none elementor-widget elementor-widget-nav-menu\" data-id=\"8fe0609\" data-element_type=\"widget\" data-settings=\"{&quot;layout&quot;:&quot;vertical&quot;,&quot;submenu_icon&quot;:{&quot;value&quot;:&quot;&lt;svg class=\\&quot;e-font-icon-svg e-fas-caret-down\\&quot; viewBox=\\&quot;0 0 320 512\\&quot; xmlns=\\&quot;http:\\\/\\\/www.w3.org\\\/2000\\\/svg\\&quot;&gt;&lt;path d=\\&quot;M31.3 192h257.3c17.8 0 26.7 21.5 14.1 34.1L174.1 354.8c-7.8 7.8-20.5 7.8-28.3 0L17.2 226.1C4.6 213.5 13.5 192 31.3 192z\\&quot;&gt;&lt;\\\/path&gt;&lt;\\\/svg&gt;&quot;,&quot;library&quot;:&quot;fa-solid&quot;}}\" data-widget_type=\"nav-menu.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t<nav aria-label=\"services-side-bar\" class=\"elementor-nav-menu--main elementor-nav-menu__container elementor-nav-menu--layout-vertical e--pointer-background e--animation-fade\">\n\t\t\t\t<ul id=\"menu-1-8fe0609\" class=\"elementor-nav-menu sm-vertical\"><li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5405\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/add-your-own-personal-discovery\/\" class=\"elementor-item\">Add your own Personal discovery<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5406\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/antibody-drug-conjugates\/\" class=\"elementor-item\">Antibody drug conjugates<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5407\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/biomedical-research-in-health-disease\/\" class=\"elementor-item\">Biomedical Research In Health &amp; Disease<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5408\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/car-t-improved-vhh-solubility\/\" class=\"elementor-item\">CAR-T: improved VHH solubility<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5409\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/crop-protection-fungi-nematodes\/\" class=\"elementor-item\">Crop protection (fungi, nematodes)<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5410\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/cytology-vhh-intrabodies\/\" class=\"elementor-item\">Cytology \u2013 VHH intrabodies<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5411\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/food-safety\/\" class=\"elementor-item\">Food Safety<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5412\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/homing-device-on-lipid-nanoparticle\/\" class=\"elementor-item\">Homing device on Lipid nanoparticle<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5413\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/minimal-linkage-error-in-microscopy\/\" class=\"elementor-item\">Minimal Linkage Error In Microscopy<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5414\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/more-affordable-sensitive-diagnostics\/\" class=\"elementor-item\">More Affordable &#038; Sensitive Diagnostics<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5415\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/novel-antibiotics\/\" class=\"elementor-item\">Novel antibiotics<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5416\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/vhh-gene-therapy-small-size\/\" class=\"elementor-item\">VHH Gene Therapy (small size)<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t\t\t<nav class=\"elementor-nav-menu--dropdown elementor-nav-menu__container\" aria-hidden=\"true\">\n\t\t\t\t<ul id=\"menu-2-8fe0609\" class=\"elementor-nav-menu sm-vertical\"><li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5405\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/add-your-own-personal-discovery\/\" class=\"elementor-item\" tabindex=\"-1\">Add your own Personal discovery<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5406\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/antibody-drug-conjugates\/\" class=\"elementor-item\" tabindex=\"-1\">Antibody drug conjugates<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5407\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/biomedical-research-in-health-disease\/\" class=\"elementor-item\" tabindex=\"-1\">Biomedical Research In Health &amp; Disease<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5408\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/car-t-improved-vhh-solubility\/\" class=\"elementor-item\" tabindex=\"-1\">CAR-T: improved VHH solubility<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5409\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/crop-protection-fungi-nematodes\/\" class=\"elementor-item\" tabindex=\"-1\">Crop protection (fungi, nematodes)<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5410\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/cytology-vhh-intrabodies\/\" class=\"elementor-item\" tabindex=\"-1\">Cytology \u2013 VHH intrabodies<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5411\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/food-safety\/\" class=\"elementor-item\" tabindex=\"-1\">Food Safety<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5412\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/homing-device-on-lipid-nanoparticle\/\" class=\"elementor-item\" tabindex=\"-1\">Homing device on Lipid nanoparticle<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5413\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/minimal-linkage-error-in-microscopy\/\" class=\"elementor-item\" tabindex=\"-1\">Minimal Linkage Error In Microscopy<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5414\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/more-affordable-sensitive-diagnostics\/\" class=\"elementor-item\" tabindex=\"-1\">More Affordable &#038; Sensitive Diagnostics<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5415\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/novel-antibiotics\/\" class=\"elementor-item\" tabindex=\"-1\">Novel antibiotics<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5416\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/vhh-gene-therapy-small-size\/\" class=\"elementor-item\" tabindex=\"-1\">VHH Gene Therapy (small size)<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-839713f e-con-full e-flex e-con e-child\" data-id=\"839713f\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-604ae6d elementor-widget elementor-widget-theme-post-featured-image elementor-widget-image\" data-id=\"604ae6d\" data-element_type=\"widget\" data-widget_type=\"theme-post-featured-image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"770\" height=\"400\" src=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-content\/uploads\/2024\/10\/VHH-Gene-Therapy-770x400-1.png\" class=\"attachment-full size-full wp-image-5026\" alt=\"\" srcset=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-content\/uploads\/2024\/10\/VHH-Gene-Therapy-770x400-1.png 770w, https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-content\/uploads\/2024\/10\/VHH-Gene-Therapy-770x400-1-300x156.png 300w, https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-content\/uploads\/2024\/10\/VHH-Gene-Therapy-770x400-1-768x399.png 768w, https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-content\/uploads\/2024\/10\/VHH-Gene-Therapy-770x400-1-600x312.png 600w\" sizes=\"(max-width: 770px) 100vw, 770px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-423b6ae st-l elementor-widget elementor-widget-drillersectiontitle\" data-id=\"423b6ae\" data-element_type=\"widget\" data-widget_type=\"drillersectiontitle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"title-area\" ><h2 class=\"sec-title subtitle-selector\">Harnessing VHHs in Gene Therapy: Expanding Therapeutic Reach in the Cytoplasm<\/h2><p>Due to their small size (~120 amino acids), the cDNA encoding a VHH is barely 0.35-0.4 kb. This makes them adaptable to gene therapy and indeed a VHH is easily accommodated within the genome of an AAV or of a lentivirus. The combination between such a gene therapy virus and a VHH unlocks the entire cytoplasm, as well as subcellular organelles, as a therapeutic playground, where numerous targets reside that were previously almost impossible to reach.<\/p><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Applications Harnessing VHHs in Gene Therapy: Expanding Therapeutic Reach in the Cytoplasm Due to their small size (~120 amino acids), the cDNA encoding a VHH is barely 0.35-0.4 kb. This makes them adaptable to gene therapy and indeed a VHH is easily accommodated within the genome of an AAV or of a lentivirus. The combination&#8230;<\/p>\n","protected":false},"featured_media":5026,"template":"","class_list":["post-5014","konta_service","type-konta_service","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-json\/wp\/v2\/konta_service\/5014","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-json\/wp\/v2\/konta_service"}],"about":[{"href":"https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-json\/wp\/v2\/types\/konta_service"}],"version-history":[{"count":19,"href":"https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-json\/wp\/v2\/konta_service\/5014\/revisions"}],"predecessor-version":[{"id":6914,"href":"https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-json\/wp\/v2\/konta_service\/5014\/revisions\/6914"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-json\/wp\/v2\/media\/5026"}],"wp:attachment":[{"href":"https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-json\/wp\/v2\/media?parent=5014"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}