{"id":5015,"date":"2024-10-21T11:20:02","date_gmt":"2024-10-21T11:20:02","guid":{"rendered":"https:\/\/explorelogicsit.net\/gulliverbiomed\/?post_type=konta_service&#038;p=5015"},"modified":"2024-10-28T11:21:41","modified_gmt":"2024-10-28T11:21:41","slug":"car-t-improved-vhh-solubility","status":"publish","type":"konta_service","link":"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/car-t-improved-vhh-solubility\/","title":{"rendered":"CAR-T: improved VHH solubility"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"5015\" class=\"elementor elementor-5015\" data-elementor-post-type=\"konta_service\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3f148e0 e-flex e-con-boxed e-con e-parent\" data-id=\"3f148e0\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-d2c3037 e-con-full services-sider-bar e-flex e-con e-child\" data-id=\"d2c3037\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-5390557 e-con-full e-flex e-con e-child\" data-id=\"5390557\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0abbe91 elementor-widget elementor-widget-heading\" data-id=\"0abbe91\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Applications<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-896503a elementor-widget__width-initial elementor-widget elementor-widget-spacer\" data-id=\"896503a\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3753f96 elementor-nav-menu--dropdown-none elementor-widget elementor-widget-nav-menu\" data-id=\"3753f96\" data-element_type=\"widget\" data-settings=\"{&quot;layout&quot;:&quot;vertical&quot;,&quot;submenu_icon&quot;:{&quot;value&quot;:&quot;&lt;svg class=\\&quot;e-font-icon-svg e-fas-caret-down\\&quot; viewBox=\\&quot;0 0 320 512\\&quot; xmlns=\\&quot;http:\\\/\\\/www.w3.org\\\/2000\\\/svg\\&quot;&gt;&lt;path d=\\&quot;M31.3 192h257.3c17.8 0 26.7 21.5 14.1 34.1L174.1 354.8c-7.8 7.8-20.5 7.8-28.3 0L17.2 226.1C4.6 213.5 13.5 192 31.3 192z\\&quot;&gt;&lt;\\\/path&gt;&lt;\\\/svg&gt;&quot;,&quot;library&quot;:&quot;fa-solid&quot;}}\" data-widget_type=\"nav-menu.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t<nav aria-label=\"services-side-bar\" class=\"elementor-nav-menu--main elementor-nav-menu__container elementor-nav-menu--layout-vertical e--pointer-background e--animation-fade\">\n\t\t\t\t<ul id=\"menu-1-3753f96\" class=\"elementor-nav-menu sm-vertical\"><li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5405\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/add-your-own-personal-discovery\/\" class=\"elementor-item\">Add your own Personal discovery<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5406\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/antibody-drug-conjugates\/\" class=\"elementor-item\">Antibody drug conjugates<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5407\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/biomedical-research-in-health-disease\/\" class=\"elementor-item\">Biomedical Research In Health &amp; Disease<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5408\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/car-t-improved-vhh-solubility\/\" class=\"elementor-item\">CAR-T: improved VHH solubility<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5409\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/crop-protection-fungi-nematodes\/\" class=\"elementor-item\">Crop protection (fungi, nematodes)<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5410\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/cytology-vhh-intrabodies\/\" class=\"elementor-item\">Cytology \u2013 VHH intrabodies<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5411\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/food-safety\/\" class=\"elementor-item\">Food Safety<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5412\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/homing-device-on-lipid-nanoparticle\/\" class=\"elementor-item\">Homing device on Lipid nanoparticle<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5413\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/minimal-linkage-error-in-microscopy\/\" class=\"elementor-item\">Minimal Linkage Error In Microscopy<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5414\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/more-affordable-sensitive-diagnostics\/\" class=\"elementor-item\">More Affordable &#038; 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Sensitive Diagnostics<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5415\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/novel-antibiotics\/\" class=\"elementor-item\" tabindex=\"-1\">Novel antibiotics<\/a><\/li>\n<li class=\"menu-item menu-item-type-post_type menu-item-object-konta_service menu-item-5416\"><a href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/all-services\/vhh-gene-therapy-small-size\/\" class=\"elementor-item\" tabindex=\"-1\">VHH Gene Therapy (small size)<\/a><\/li>\n<\/ul>\t\t\t<\/nav>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-96e5955 e-con-full e-flex e-con e-child\" data-id=\"96e5955\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b709ae2 elementor-widget elementor-widget-theme-post-featured-image elementor-widget-image\" data-id=\"b709ae2\" data-element_type=\"widget\" data-widget_type=\"theme-post-featured-image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"770\" height=\"400\" src=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-content\/uploads\/2024\/10\/CAR-T-770x400-1.png\" class=\"attachment-full size-full wp-image-5027\" alt=\"\" srcset=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-content\/uploads\/2024\/10\/CAR-T-770x400-1.png 770w, https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-content\/uploads\/2024\/10\/CAR-T-770x400-1-300x156.png 300w, https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-content\/uploads\/2024\/10\/CAR-T-770x400-1-768x399.png 768w, https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-content\/uploads\/2024\/10\/CAR-T-770x400-1-600x312.png 600w\" sizes=\"(max-width: 770px) 100vw, 770px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c493213 st-l elementor-widget elementor-widget-drillersectiontitle\" data-id=\"c493213\" data-element_type=\"widget\" data-widget_type=\"drillersectiontitle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"title-area\" ><h2 class=\"sec-title subtitle-selector\">Enhancing CAR-T Cell Function with VHHs: Overcoming Exhaustion and Improving Targeting<\/h2><p>It is know that T-cells used in CAR-T at times become exhausted prematurely before performing their actual therapeutic role. This may be caused by VL and VH mispairing (originating from the scFvs), triggering premature signal cascade activation. The monomeric nature of VHHs, in addition to their increased hydrophilicity compared to scFvs, points to VHHs as a potent instrument to direct T-cells to home in to the tumor.<\/p><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Applications Enhancing CAR-T Cell Function with VHHs: Overcoming Exhaustion and Improving Targeting It is know that T-cells used in CAR-T at times become exhausted prematurely before performing their actual therapeutic role. This may be caused by VL and VH mispairing (originating from the scFvs), triggering premature signal cascade activation. The monomeric nature of VHHs, in&#8230;<\/p>\n","protected":false},"featured_media":5027,"template":"","class_list":["post-5015","konta_service","type-konta_service","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-json\/wp\/v2\/konta_service\/5015","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-json\/wp\/v2\/konta_service"}],"about":[{"href":"https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-json\/wp\/v2\/types\/konta_service"}],"version-history":[{"count":13,"href":"https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-json\/wp\/v2\/konta_service\/5015\/revisions"}],"predecessor-version":[{"id":6917,"href":"https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-json\/wp\/v2\/konta_service\/5015\/revisions\/6917"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-json\/wp\/v2\/media\/5027"}],"wp:attachment":[{"href":"https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-json\/wp\/v2\/media?parent=5015"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}