{"id":6426,"date":"2024-10-23T10:56:42","date_gmt":"2024-10-23T10:56:42","guid":{"rendered":"https:\/\/explorelogicsit.net\/gulliverbiomed\/?page_id=6426"},"modified":"2024-10-23T11:17:50","modified_gmt":"2024-10-23T11:17:50","slug":"manduhai-focal-adhesion-kinase-fak-vhh","status":"publish","type":"page","link":"https:\/\/explorelogicsit.net\/gulliverbiomed\/manduhai-focal-adhesion-kinase-fak-vhh\/","title":{"rendered":"Manduhai Focal Adhesion Kinase (FAK) VHH"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"6426\" class=\"elementor elementor-6426\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0eed520 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0eed520\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-40763db\" data-id=\"40763db\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-68e73a4 elementor-reverse-tablet elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"68e73a4\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-58b170e\" data-id=\"58b170e\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t<div class=\"elementor-element elementor-element-59913e9 e-flex e-con-boxed e-con e-parent\" data-id=\"59913e9\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\r\n\t\t<div class=\"elementor-element elementor-element-a6a1b0b st-l elementor-widget elementor-widget-drillersectiontitle\" data-id=\"a6a1b0b\" data-element_type=\"widget\" data-widget_type=\"drillersectiontitle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"title-area\" ><h2 class=\"sec-title subtitle-selector\">Recombinant anti-human FAK Manduhai nanobody 54<\/h2><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0ab4ef1 st-l elementor-widget elementor-widget-drillersectiontitle\" data-id=\"0ab4ef1\" data-element_type=\"widget\" data-widget_type=\"drillersectiontitle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"title-area\" ><h3 class=\"sec-title subtitle-selector\">PRODUCT SPECIFICATION<\/h3><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2c4a038 elementor-widget elementor-widget-text-editor\" data-id=\"2c4a038\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Recombinant Manduhai anti-mouse Focal adhesion kinase (FAK) nanobody 54.<\/p><p><strong>Catalogue number:<\/strong> sdAb-FAK-Nb54\/Man<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8cb473a e-flex e-con-boxed e-con e-parent\" data-id=\"8cb473a\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fde3ce9 elementor-widget elementor-widget-heading\" data-id=\"fde3ce9\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Background \n<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-18a81ed elementor-widget elementor-widget-text-editor\" data-id=\"18a81ed\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Focal adhesion kinase is a cytosolic (non-receptor) tyrosine kinase of 125 kDa, concentrated in focal adhesions. The FERM (4.1 protein, Ezrin, Radixin, Moesin) and kinase domains form an autoinhibitory association. The FAT domain (focal adhesion targeting domain) directs the kinase to focal adhesions. FAK is found in most cells. FAK promotes cell migration by activating a signaling pathway that induces turn-over of cell contacts with the underlying matrix. During apoptosis, FAK is cleaved by caspase 3 and contributes to loss of focal contacts, cell rounding and formation of blebs. At the organismal level, FAK is required for normal early embryonic development, placenta and heart development. FAK regulates numerous signaling pathways (integring signal transduction, GPRCs, LDL, netrin receptors.<br \/>Substrates:Src kinase, BMX, PIK3R1, PAX, STAT1,\u2026<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a49b21e e-flex e-con-boxed e-con e-parent\" data-id=\"a49b21e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0bce28a elementor-widget elementor-widget-heading\" data-id=\"0bce28a\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Derivatized FAK nanobodies for click chemistry<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6688f19 elementor-widget elementor-widget-text-editor\" data-id=\"6688f19\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tThe Manduhai FAK Nanobodies carry a carboxy-terminal para-azido-Phe residue, enzymatically inserted. This residue is the same as natural Phe, except that it carries an azido group in its aromatic ring (-N3). As a result, the nanobody is endowed with a singular reactive group, allowing downstream click chemistry. Reproducible and site-specific labeling becomes standard in this way. Through this modification the antigen binding properties of the nanobody remain unchanged because the carboxy-terminal region of a nanobody is generally not involved in antigen binding. \t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7964a67 e-flex e-con-boxed e-con e-parent\" data-id=\"7964a67\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9c24052 elementor-widget elementor-widget-heading\" data-id=\"9c24052\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Source and properties\n<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1be9a5f elementor-widget elementor-widget-text-editor\" data-id=\"1be9a5f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tFAK Nanobodies were raised by immunizing a llama with a recombinant FAK protein fragment.\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-28a0e57 e-flex e-con-boxed e-con e-parent\" data-id=\"28a0e57\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-ee63cab e-con-full e-flex e-con e-child\" data-id=\"ee63cab\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0f35515 elementor-widget elementor-widget-heading\" data-id=\"0f35515\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Availability: <\/p>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-094dd25 e-con-full e-flex e-con e-child\" data-id=\"094dd25\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-51f467d elementor-widget elementor-widget-text-editor\" data-id=\"51f467d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tManduhai FAK Nanobodies come with a COOH-terminal para-Azido Phe residue.\nAvailable in 25 \u00b5g, 50 \u00b5g, 100 \u00b5g quantities. For bulk amounts, please inquire.\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-350568b e-con-full e-flex e-con e-child\" data-id=\"350568b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1bd9022 elementor-widget elementor-widget-heading\" data-id=\"1bd9022\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Expression host:<\/p>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1008d95 e-con-full e-flex e-con e-child\" data-id=\"1008d95\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4c371df elementor-widget elementor-widget-text-editor\" data-id=\"4c371df\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tVHH single domain antibody purified from E. coli\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cbed1d4 e-con-full e-flex e-con e-child\" data-id=\"cbed1d4\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-21f6a5d elementor-widget elementor-widget-heading\" data-id=\"21f6a5d\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Cross reactivity: <\/p>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-72890f4 e-con-full e-flex e-con e-child\" data-id=\"72890f4\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-aa02845 elementor-widget elementor-widget-text-editor\" data-id=\"aa02845\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tReactivity of this nanobody with mouse and human FAK has been established. Other\nspecies have not yet been tested.\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-412940b e-con-full e-flex e-con e-child\" data-id=\"412940b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-277cd4b elementor-widget elementor-widget-heading\" data-id=\"277cd4b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Storage buffer:<\/p>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6a02650 e-con-full e-flex e-con e-child\" data-id=\"6a02650\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6e73f10 elementor-widget elementor-widget-text-editor\" data-id=\"6e73f10\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t20 mM Tris-HCl pH 8.0, 150 mM NaCl, 1mM DTT. \t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e3a97df e-con-full e-flex e-con e-child\" data-id=\"e3a97df\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-476fd9f elementor-widget elementor-widget-heading\" data-id=\"476fd9f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Stability: <\/p>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ee711da e-con-full e-flex e-con e-child\" data-id=\"ee711da\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4555167 elementor-widget elementor-widget-text-editor\" data-id=\"4555167\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tStore at -20\u00b0C upon arrival. For long term storage, aliquot and store at -80\u00b0C. Avoid repeated freeze\/thaw cycles.\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b997041 e-con-full e-flex e-con e-child\" data-id=\"b997041\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d30335f elementor-widget elementor-widget-heading\" data-id=\"d30335f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Product citations:<\/p>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-67d82ff e-con-full e-flex e-con e-child\" data-id=\"67d82ff\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-22d3c00 elementor-widget elementor-widget-text-editor\" data-id=\"22d3c00\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Please enquire about other FAK FAT nanobodies at <a href=\"mailto:info@gulliverbiomed.com\">info@gulliverbiomed.com<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fe6c600 elementor-widget elementor-widget-kontabutton\" data-id=\"fe6c600\" data-element_type=\"widget\" data-widget_type=\"kontabutton.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<!-- Button --><div class=\"btn-wrapper center\"><a class=\"th-btn\" href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-content\/uploads\/2024\/10\/Manduhai-FAK-54-update.pdf\" target=\"_blank\">Read More<i class=\"fa-regular fa-arrow-right ms-2\"><\/i><\/a><\/div><!-- End Button -->\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-317397f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"317397f\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-284caf6\" data-id=\"284caf6\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-7ce4b8c elementor-reverse-tablet elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7ce4b8c\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-775dc84\" data-id=\"775dc84\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3edb266 e-flex e-con-boxed e-con e-parent\" data-id=\"3edb266\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2485f0d st-l elementor-widget elementor-widget-drillersectiontitle\" data-id=\"2485f0d\" data-element_type=\"widget\" data-widget_type=\"drillersectiontitle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"title-area\" ><h2 class=\"sec-title subtitle-selector\">Recombinant anti-human FAK Manduhai nanobody 80<\/h2><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8372a93 st-l elementor-widget elementor-widget-drillersectiontitle\" data-id=\"8372a93\" data-element_type=\"widget\" data-widget_type=\"drillersectiontitle.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"title-area\" ><h3 class=\"sec-title subtitle-selector\">PRODUCT SPECIFICATION<\/h3><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-02235b4 elementor-widget elementor-widget-text-editor\" data-id=\"02235b4\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Recombinant Manduhai anti-mouse Focal adhesion kinase (FAK) nanobody 80.<\/p><p><strong>Catalogue number:<\/strong> sdAb-FAK-Nb80\/Man.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-87384e0 e-flex e-con-boxed e-con e-parent\" data-id=\"87384e0\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2160494 elementor-widget elementor-widget-heading\" data-id=\"2160494\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Background \n<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-374d672 elementor-widget elementor-widget-text-editor\" data-id=\"374d672\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tFocal adhesion kinase is a cytosolic (non-receptor) tyrosine kinase of 125 kDa, concentrated in focal adhesions. The FERM (4.1 protein, Ezrin, Radixin, Moesin) and kinase domains form an autoinhibitory association. The FAT domain (focal adhesion targeting domain) directs the kinase to focal adhesions. FAK is found in most cells. FAK promotes cell migration by activating a signaling pathway that induces turn-over of cell contacts with the underlying matrix. During apoptosis, FAK is cleaved by caspase 3 and contributes to loss of focal contacts, cell rounding and formation of blebs. At the organismal level, FAK is required for normal early embryonic development, placenta and heart development. FAK regulates numerous signaling pathways (integring signal transduction, GPRCs, LDL, netrin receptors.\nSubstrates:Src kinase, BMX, PIK3R1, PAX, STAT1,\u2026\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1fbcb81 e-flex e-con-boxed e-con e-parent\" data-id=\"1fbcb81\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ded921e elementor-widget elementor-widget-heading\" data-id=\"ded921e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Derivatized FAK nanobodies for click chemistry<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c5c9f40 elementor-widget elementor-widget-text-editor\" data-id=\"c5c9f40\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>The Manduhai FAK Nanobodies carry a carboxy-terminal para-azido-Phe residue, enzymatically inserted. This residue is the same as natural Phe, except that it carries an azido group in its aromatic ring (-N3). As a result, the nanobody is endowed with a singular reactive group, allowing downstream click chemistry. Reproducible and site-specific labeling becomes standard in this way. Through this modification the antigen binding properties of the nanobody remain unchanged because the carboxy-terminal region of a nanobody is generally not<br \/>involved in antigen binding.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1fe4160 e-flex e-con-boxed e-con e-parent\" data-id=\"1fe4160\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-90daca9 elementor-widget elementor-widget-heading\" data-id=\"90daca9\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Source and properties\n<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b297407 elementor-widget elementor-widget-text-editor\" data-id=\"b297407\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>FAK Nanobodies were raised by immunizing a llama with a recombinant FAK protein fragment.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2116d40 e-flex e-con-boxed e-con e-parent\" data-id=\"2116d40\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-ffa37ed e-con-full e-flex e-con e-child\" data-id=\"ffa37ed\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d642681 elementor-widget elementor-widget-heading\" data-id=\"d642681\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Availability: <\/p>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5a5cc2e e-con-full e-flex e-con e-child\" data-id=\"5a5cc2e\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9b8b622 elementor-widget elementor-widget-text-editor\" data-id=\"9b8b622\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tManduhai FAK Nanobodies come with a COOH-terminal para-Azido Phe residue.\nAvailable in 25 \u00b5g, 50 \u00b5g, 100 \u00b5g quantities. For bulk amounts, please inquire.\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5e0be33 e-con-full e-flex e-con e-child\" data-id=\"5e0be33\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0499038 elementor-widget elementor-widget-heading\" data-id=\"0499038\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Expression host:<\/p>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9eef138 e-con-full e-flex e-con e-child\" data-id=\"9eef138\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f975803 elementor-widget elementor-widget-text-editor\" data-id=\"f975803\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tVHH single domain antibody purified from E. coli\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0d2ee03 e-con-full e-flex e-con e-child\" data-id=\"0d2ee03\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ce87247 elementor-widget elementor-widget-heading\" data-id=\"ce87247\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Cross reactivity: <\/p>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ae3e4ad e-con-full e-flex e-con e-child\" data-id=\"ae3e4ad\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0539b0c elementor-widget elementor-widget-text-editor\" data-id=\"0539b0c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tReactivity of this nanobody with mouse and human FAK has been established. Other species have not yet been tested\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8cc4fc4 e-con-full e-flex e-con e-child\" data-id=\"8cc4fc4\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a012bc5 elementor-widget elementor-widget-heading\" data-id=\"a012bc5\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Storage buffer:<\/p>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c37771d e-con-full e-flex e-con e-child\" data-id=\"c37771d\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6b7d821 elementor-widget elementor-widget-text-editor\" data-id=\"6b7d821\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t20 mM Tris-HCl pH 8.0, 150 mM NaCl, 1mM DTT.\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b1ecfa3 e-con-full e-flex e-con e-child\" data-id=\"b1ecfa3\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c54e383 elementor-widget elementor-widget-heading\" data-id=\"c54e383\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Stability: <\/p>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-071c14e e-con-full e-flex e-con e-child\" data-id=\"071c14e\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-89b2f29 elementor-widget elementor-widget-text-editor\" data-id=\"89b2f29\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tStore at -20\u00b0C upon arrival. For long term storage, aliquot and store at -80\u00b0C. Avoid repeated freeze\/thaw cycles.\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-63602dd e-con-full e-flex e-con e-child\" data-id=\"63602dd\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4f52d34 elementor-widget elementor-widget-heading\" data-id=\"4f52d34\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Product citations:<\/p>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c65821d e-con-full e-flex e-con e-child\" data-id=\"c65821d\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fed8c8e elementor-widget elementor-widget-text-editor\" data-id=\"fed8c8e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Please enquire about other FAK FAT nanobodies at <a href=\"mailto:info@gulliverbiomed.com\">info@gulliverbiomed.com<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-46b18af elementor-widget elementor-widget-kontabutton\" data-id=\"46b18af\" data-element_type=\"widget\" data-widget_type=\"kontabutton.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<!-- Button --><div class=\"btn-wrapper center\"><a class=\"th-btn\" href=\"https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-content\/uploads\/2024\/10\/Manduhai-FAK-80-update.pdf\" target=\"_blank\">Read More<i class=\"fa-regular fa-arrow-right ms-2\"><\/i><\/a><\/div><!-- End Button -->\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Recombinant anti-human FAK Manduhai nanobody 54 PRODUCT SPECIFICATION Recombinant Manduhai anti-mouse Focal adhesion kinase (FAK) nanobody 54. Catalogue number: sdAb-FAK-Nb54\/Man Background Focal adhesion kinase is a cytosolic (non-receptor) tyrosine kinase of 125 kDa, concentrated in focal adhesions. The FERM (4.1 protein, Ezrin, Radixin, Moesin) and kinase domains form an autoinhibitory association. The FAT domain (focal&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-builder.php","meta":{"inline_featured_image":false,"footnotes":""},"class_list":["post-6426","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-json\/wp\/v2\/pages\/6426","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-json\/wp\/v2\/comments?post=6426"}],"version-history":[{"count":16,"href":"https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-json\/wp\/v2\/pages\/6426\/revisions"}],"predecessor-version":[{"id":6464,"href":"https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-json\/wp\/v2\/pages\/6426\/revisions\/6464"}],"wp:attachment":[{"href":"https:\/\/explorelogicsit.net\/gulliverbiomed\/wp-json\/wp\/v2\/media?parent=6426"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}